Curcuma longa (Curcumin) is the most researched compound for its broad anti-inflammatory activities and decreases many inflammatory pathways and several molecules involved in inflammation.
Curcumin inhibits these inflammatory pathways by preventing and inhibiting the activation of the inflammatory mediator NF-kB; - the key inflammatory mediator that is the common intracellular inflammatory signal to the following inflammatory pathways in the body. These inflammatory substances include phospholipase, lipoxygenase, cyclo-oxygenase-2 (COX-2), leukotrienes, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1, inferno-inducible protein, tumor necrosis factor-a (TNF-a), and interleukin-12 (IL-12).
Curcumin is a powerful antioxidant (ORAC value of 127,068 v’s Blueberries 9,621) and can assist in protecting the body from the damaging effects of free radical damage mainly superoxide and peroxyl radicals. This powerful antioxidant activity is thought to be the reason for its positive effect on heart health and cancer. Research has also suggested that Turmeric may show beneficial actions in the development of cancer through its powerful antioxidant protection. It also supports a healthy digestive system and function of the liver through the stimulation of bile and its antioxidant and anti- inflammatory effects.
The reason Curcumin is indicated for manyconditions throughout the body is through modulating chronic inflammation. Chronic pain has many causes, but all share one common denominator: Inflammation.
Boswellia serrata Gum (Boswellia): also known as frankincense which has been used for thousands of years in traditional Ayurvedic medicine. It is especially beneficial for its ability to manage inflammatory disorders as it inhibits the inflammatory pathway 5-lipoxygenase and blocks leukotriene synthesis, therefore reducing inflammation in the body making it especially beneficial in supporting joint health and mobility.
Zingiber officinale Rhizome (Ginger): Ginger is highly valued in Chinese Medicine and has powerful anti-inflammatory properties by suppressing the inflammatory pathways COX – 2 and leukotrienes pathway. Ginger has many actions including improving circulation but is very good for supporting joint mobility and suppleness.
Withania somnifera Root (Ashwagandha) Extract is known for its adaptogen properties, however it is a natural anti-inflammatory especially when combined with frankincense and turmeric to significantly reduce joint discomfort easing arthritis pain.
Bioperine® (Black Pepper): Black pepper inhibits enzymes that breakdown the curcumin (slows it down from being metabolised) increasing absorption time. It also activates the enzymes which produce cAMP – causing dilation of blood vessels in the intestines, increasing transit time and larger blood vessels increase absorption. It therefore increases the absorption of Turmeric (curcumin) which is difficult to absorb on its own.